(2 references)-
- 抗原 See all SIT1 抗体
- SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SIT1 antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The antibody SIT-01 reacts with an intracellular epitope of SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs. It weakly crossreacts with murine SIT.
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- Bacterially produced recombinant intracellular fragment of human SIT.
- 克隆位点
- SIT-01
- 亚型
- IgG1
- Top Product
- Discover our top product SIT1 Primary Antibody
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anti-Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1) antibody
SIT1 适用: 人 WB, IP, FACS 宿主: 小鼠 Monoclonal SIT-01 unconjugated
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- 应用备注
- Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.
- 说明
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
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Do not freeze.
Avoid prolonged exposure to light. - 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- 抗原
- SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))
- 别名
- SIT (SIT1 产品)
- 别名
- SIT1 antibody, RP11-331F9.5 antibody, SIT antibody, SIT-R antibody, Sit antibody, signaling threshold regulating transmembrane adaptor 1 antibody, suppression inducing transmembrane adaptor 1 antibody, SIT1 antibody, Sit1 antibody
- 背景
- Signaling threshold regulating transmembrane adapt,SIT is a 21 kDa transmembrane adaptor protein expressed exclusively in lymphoid organs. It acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.,SIT1
- 基因ID
- 27240
- UniProt
- Q9Y3P8
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