CD6 抗体
(3 references)Quick Overview for CD6 抗体 (ABIN94206)
抗原
See all CD6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD6 Purified
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特异性
- The antibody MEM-98 reacts with an extracellular epitope of CD6, a 100-130 kDa single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Human CD6 antigen purified by immunoaffinity chromatography from HBP-ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone).
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亚型
- IgG1
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anti-CD6 (CD6) (AA 18-199) antibody
CD6 适用: 人 FACS, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 5A10A2 unconjugated
anti-CD6 (CD6) (AA 18-199) antibodyCD6 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 6B11G6 unconjugated
anti-CD6 (CD6) (AA 472-668) antibodyCD6 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 6B9 unconjugated
anti-CD6 (CD6) (AA 30-204) antibodyCD6 适用: 小鼠 FACS, WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD6 (CD6) (AA 477-644) antibodyCD6 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD6 (CD6) antibodyCD6 适用: 人 FACS, IF, IHC, StM 宿主: 兔 Monoclonal C6-2884R unconjugated Recombinant Antibody
anti-CD6 (CD6) antibodyCD6 适用: 人 FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal 3F7B5 unconjugated
anti-CD6 (CD6) (AA 472-668) antibodyCD6 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-CD6 (CD6) (AA 424-668) antibodyCD6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD6 (CD6) antibodyCD6 适用: 人, 小鼠 FACS, IF 宿主: 小鼠 Monoclonal SPV-L14 unconjugated
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应用备注
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Flow cytometry: Recommended dilution: 2 μg/mL.
Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: spleen.
Western blotting: Recommended dilution: 1-2 μg/mL, non-reducing conditions. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4351-61, (2007) (PubMed).
: "CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76." in: Molecular and cellular biology, Vol. 26, Issue 17, pp. 6727-38, (2006) (PubMed).
: "Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102." in: Folia biologica, Vol. 35, Issue 5, pp. 289-97, (1990) (PubMed).
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: "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4351-61, (2007) (PubMed).
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- CD6
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别名
- CD6
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背景
- CD6 Molecule,CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.,T12, TP120
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基因ID
- 923
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UniProt
- P30203
抗原
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