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ICAM1 抗体

There is 1 publication for this product available. The 小鼠 单克隆 anti-ICAM1 antibody is suitable to detect ICAM1 in samples from 人. It has been validated for FACS 和 IP.
产品编号 ABIN94175
发货至: 中国
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Quick Overview for ICAM1 抗体 (ABIN94175)

抗原

See all ICAM1 抗体
ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

适用

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小鼠

克隆类型

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单克隆

标记

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This ICAM1 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunoprecipitation (IP)

克隆位点

MEM-112
  • 原理

    Anti-Hu CD54 Purified

    交叉反应 (详细)

    Human

    产品特性

    The antibody MEM-112 reacts with an extracellular epitope of CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus). The expression of CD54 is upregulated by activation, it is expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells.

    纯化方法

    Purified by protein-A affinity chromatography.

    纯度

    > 95 % (by SDS-PAGE)

    免疫原

    Raji Burkitt's lymphoma cell line Raji

    亚型

    IgG1
  • 应用备注

    Flow cytometry: Recommended dilution: 0.5-4 μg/mL.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • Leeuwenberg, Smeets, Neefjes, Shaffer, Cinek, Jeunhomme, Ahern, Buurman: "E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro." in: Immunology, Vol. 77, Issue 4, pp. 543-9, (1993) (PubMed).

  • 抗原

    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

    别名

    CD54

    背景

    Intercellular adhesion molecule 1,CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.,ICAM-1, BB2, P3.58

    基因ID

    3383

    UniProt

    P05362

    途径

    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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