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CD33 抗体 (Biotin)

This anti-CD33 antibody is a 小鼠 单克隆 antibody detecting CD33 in FACS. Suitable for 人 和 Non-Human Primate. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN94073
发货至: 中国

Quick Overview for CD33 抗体 (Biotin) (ABIN94073)

抗原

See all CD33 抗体
CD33

适用

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人, Non-Human Primate

宿主

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小鼠

克隆类型

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  • 1
单克隆

标记

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This CD33 antibody is conjugated to Biotin

应用范围

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Flow Cytometry (FACS)

克隆位点

HIM3-4
  • 原理

    Anti-Hu CD33 Biotin

    特异性

    The antibody HIM3-4 reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells, it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

    交叉反应 (详细)

    Human, Non-Human Primates

    纯化方法

    Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

    免疫原

    NFMY-9s human cell line

    亚型

    IgG1
  • 应用备注

    Flow cytometry: Recommended dilution: 1-12 μg/mL

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze.
    Avoid prolonged exposure to light.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • McCormack, Muji?, Osdal, Bruserud, Gjertsen: "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia." in: Blood, Vol. 121, Issue 7, pp. e34-42, (2013) (PubMed).

  • 抗原

    CD33

    别名

    CD33

    背景

    CD33 Molecule,CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.,SIGLEC3, p67

    基因ID

    945

    UniProt

    P20138
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