WB: 0.2-1 µg/mL Optimal conditions should be determined by the investigator.
限制
仅限研究用
状态
Lyophilized
浓度
Lot specific
缓冲液
Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
注意事项
Avoid repeated freeze/thaw cycles.
储存条件
4 °C/-20 °C
储存方法
Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
抗原
MDC1
(Mdc1 (MDC1))
别名
MDC1
背景
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Synonyms: Polyclonal MDC1 antibody, Anti-MDC1 antibody, mediator of DNA-damage checkpoint 1 antibody, DKFZp781A0122 antibody, KIAA0170 antibody, MGC166888 antibody, NFBD1 antibody.