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Cullin 2 抗体 (Middle Region)

This anti-Cullin 2 antibody is a 兔 多克隆 antibody detecting Cullin 2 in WB. Suitable for 人, 小鼠, 大鼠, 犬, Cow 和 非洲爪蟾.
产品编号 ABIN926903
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Cullin 2 抗体 (Middle Region) (ABIN926903)

抗原

See all Cullin 2 (CUL2) 抗体
Cullin 2 (CUL2)

适用

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人, 小鼠, 大鼠, 犬, Cow, 非洲爪蟾

宿主

  • 82
  • 2
  • 1

克隆类型

  • 63
  • 22
多克隆

标记

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This Cullin 2 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    Middle Region

    交叉反应

    小鼠, 大鼠, 犬, 牛, Frog

    纯化方法

    Purified

    免疫原

    CUL2 antibody was raised in rabbit using the middle region of CUL2 as the immunogen
  • 应用备注

    WB: 0.2-1 µg/mL
    Optimal conditions should be determined by the investigator.

    说明

    CUL2 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this CUL2 antibody

    限制

    仅限研究用
  • 状态

    Lyophilized

    浓度

    Lot specific

    缓冲液

    Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

    注意事项

    Avoid repeated freeze/thaw cycles.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
  • 抗原

    Cullin 2 (CUL2)

    别名

    CUL2

    背景

    CUL2 is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This protein may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). Synonyms: Polyclonal CUL2 antibody, Anti-CUL2 antibody, cullin 2 antibody, MGC131970 antibody.

    途径

    M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interactome
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