PVRL2 抗体
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北京 101111
Quick Overview for PVRL2 抗体 (ABIN920706)
抗原
See all PVRL2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Reacts with nectin-2.
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纯化方法
- Purified
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免疫原
- The extracellular domain of mouse nectin-2.
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亚型
- IgG2a
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应用备注
- Immunohistochemistry: (frozen sections) Use at a 1:10 dilution. Flow cytometry: Use at a 1:10 dilution. Western blot: Use at a 1:10 dilution. Fixation with PFA or acetone/methanol is recommended.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 1 mL of 100 µg/mL
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储存条件
- 4 °C
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- PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))
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别名
- Nectin-2
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背景
- Nectin (originally isolated as poliovirus receptor- related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is co-localized with afadin at cadherin-based cell-cell adherence juctions in various tissues and cell lines. The nectin family consists of nectin-1, nectin-2 and nectin-3. Nectin-2 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cells lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice. Synonyms: PRR2, CD112
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization
抗原
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