TLR6 抗体 (N-Term)
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Quick Overview for TLR6 抗体 (N-Term) (ABIN920640)
抗原
See all TLR6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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产品特性
- Positive Control: Jurkat cell lysate. Located in the membrane TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre- dendritic cells and dermal microvessel endothelial cells.
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纯化方法
- Antigen Immunoaffinity purified
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免疫原
- Rabbit polyclonal TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR6.
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亚型
- IgG
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应用备注
- Western blot: use at 1-2 µg/mL. Immunocytochemistry: use at 10 µg/mL
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限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.02% sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- TLR6 (Toll-Like Receptor 6 (TLR6))
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背景
- Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identity. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 heterodimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but can also lead to apoptotic responses. Synonyms:
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分子量
- 96 kDa
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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