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TLR6 抗体 (N-Term)

The 兔 多克隆 anti-TLR6 antibody (ABIN920640) specifically detects TLR6 in WB 和 ICC. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN920640
发货至: 中国
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Quick Overview for TLR6 抗体 (N-Term) (ABIN920640)

抗原

See all TLR6 抗体
TLR6 (Toll-Like Receptor 6 (TLR6))

适用

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人, 小鼠

宿主

  • 51
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克隆类型

  • 51
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多克隆

标记

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This TLR6 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunocytochemistry (ICC)
  • 抗原表位

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    N-Term

    产品特性

    Positive Control: Jurkat cell lysate. Located in the membrane TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre- dendritic cells and dermal microvessel endothelial cells.

    纯化方法

    Antigen Immunoaffinity purified

    免疫原

    Rabbit polyclonal TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR6.

    亚型

    IgG
  • 应用备注

    Western blot: use at 1-2 µg/mL. Immunocytochemistry: use at 10 µg/mL

    限制

    仅限研究用
  • 缓冲液

    Phosphate buffered saline with 0.02% sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • 抗原

    TLR6 (Toll-Like Receptor 6 (TLR6))

    背景

    Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identity. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 heterodimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but can also lead to apoptotic responses. Synonyms:

    分子量

    96 kDa

    途径

    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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