TLR4 抗体 (N-Term)
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Quick Overview for TLR4 抗体 (N-Term) (ABIN920639)
抗原
See all TLR4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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产品特性
- Positive Control: Located in the membrane and highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
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纯化方法
- Antigen Immunoaffinity purified
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免疫原
- Rabbit polyclonal TLR4 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR4.
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亚型
- IgG
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应用备注
- Western blot: use at 2-5 µg/mL
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限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.02% sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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背景
- Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Studies with TLR4 deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram- negative sepsis. Synonyms:
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分子量
- 95 kDa
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
抗原
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