TLR3 抗体 (N-Term)
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Quick Overview for TLR3 抗体 (N-Term) (ABIN920638)
抗原
See all TLR3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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产品特性
- Positive Control: Located in the membrane and expressed at high levels in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.
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纯化方法
- Antigen Immunoaffinity purified
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免疫原
- Rabbit polyclonal TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR3.
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亚型
- IgG
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应用备注
- Western blot: use at 1-2 µg/mL
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限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.02% sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- TLR3 (Toll-Like Receptor 3 (TLR3))
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背景
- Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded RNA, as a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as influenza A and West Nile Virus and can mediate entry of at least West Nile virus. Synonyms:
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分子量
- 103.8 kDa
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途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
抗原
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