TLR9 抗体 (Internal Region)
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Quick Overview for TLR9 抗体 (Internal Region) (ABIN920629)
抗原
See all TLR9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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产品特性
- Positive Control: Jurkat cell lysate. Located in the membrane, and highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
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纯化方法
- Antigen Immunoaffinity purified
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免疫原
- Rabbit polyclonal TLR9 antibody was raised against a peptide corresponding to 15 amino acids near the center of human TLR9.
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亚型
- IgG
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应用备注
- Western blot: use at 0.5-1 µg/mL
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限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.02% sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- TLR9 (Toll-Like Receptor 9 (TLR9))
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背景
- Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. TLR9 forms a subfamily with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TRL9 is strictly dependent on MyD88. Synonyms:
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分子量
- 116 kDa
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途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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