Positive Control: Mouse spleen tissue lysate. Located in membrane, and highly expressed in spleen, lymph node, tonsil, and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
纯化方法
Antigen Immunoaffinity purified
免疫原
Rabbit polyclonal TLR9 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human TLR9.
Phosphate buffered saline with 0.02% sodium azide.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
抗原
TLR9
(Toll-Like Receptor 9 (TLR9))
背景
Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. TLR9 forms a subfamily with TLR7 and TLR8 that recognize viral RNA and CpG DNA sequences and are localized in intracellular acidic compartments such as the phagolysosome. Unlike other TLRs which act through adaptor molecules such as TOLLIP, TIRAP, TRIF, and MyD88 to activate various kinases and transcription factors to respond to potential infection, TRL9 is strictly dependent on MyD88. Synonyms: