SIRT4 抗体 (AA 51-150) (Biotin)
Quick Overview for SIRT4 抗体 (AA 51-150) (Biotin) (ABIN915295)
抗原
See all SIRT4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-150
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish,Drosophila
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
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亚型
- IgG
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anti-Sirtuin 4 (SIRT4) (AA 28-314) antibody
SIRT4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 51-150) antibodySIRT4 适用: 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 60-255) antibodySIRT4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (C-Term) antibodyVerified SIRT4 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 215-314) antibodySIRT4 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6G6D2 unconjugated
anti-Sirtuin 4 (SIRT4) (Middle Region) antibodySIRT4 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 马, 兔, 绵羊, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 29-260) antibodySIRT4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 26-333) antibodySIRT4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 215-314) antibodySIRT4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Sirtuin 4 (SIRT4) (AA 216-265) antibodySIRT4 适用: 人, 犬, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- SIRT4 (Sirtuin 4 (SIRT4))
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别名
- SIRT4
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背景
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Synonyms: SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4, Regulatory protein SIR2 homolog 4, SIR2-like protein 4, SIRT4
Background: Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
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基因ID
- 23409
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UniProt
- Q9Y6E7
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途径
- Negative Regulation of Hormone Secretion
抗原
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