PIK3CB 抗体 (AA 701-800) (Biotin)
Quick Overview for PIK3CB 抗体 (AA 701-800) (Biotin) (ABIN911070)
抗原
See all PIK3CB 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 701-800
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Cow,Sheep,Pig,Horse,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human PI3 Kinase p110 beta
-
亚型
- IgG
-
-
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 807-1070) antibody
PIK3CB 适用: 人 WB, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 524-703) antibodyPIK3CB 适用: 人 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 321-507) antibodyPIK3CB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (pSer1070) antibodyPIK3CB 适用: 人, 小鼠, 大鼠, 犬, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 147-256) antibodyPIK3CB 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 4H2 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 147-256) antibodyPIK3CB 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 10D5 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 771-1070) antibodyPIK3CB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 556-598), (Middle Region) antibodyPIK3CB 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) antibodyPIK3CB 适用: 人 WB, ELISA, IP 宿主: 兔 Monoclonal 5A9 unconjugated Recombinant Antibody
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 124-154), (N-Term) antibodyPIK3CB 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB11625 unconjugated
-
-
应用备注
-
WB 1:300-5000
IHC-P 1:200-400 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C for 12 months.
-
有效期
- 12 months
-
-
- PIK3CB (Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB))
-
别名
- PI3 Kinase p110 beta
-
背景
-
Synonyms: PI3K, PIK3C1, P110BETA, PI3KBETA, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase subunit beta, PI3K-beta, PtdIns-3-kinase subunit beta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, PtdIns-3-kinase subunit p110-beta, PIK3CB
Background: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.
-
基因ID
- 5291
-
UniProt
- P42338
抗原
-
