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Cortactin 抗体 (pThr466) (AbBy Fluor® 555)

CTTN 适用: 人 WB, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 555
产品编号 ABIN879742
发货至: 中国
  • 抗原 See all Cortactin (CTTN) 抗体
    Cortactin (CTTN)
    抗原表位
    • 14
    • 13
    • 12
    • 7
    • 7
    • 6
    • 6
    • 3
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    • 3
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    • 1
    • 1
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    pThr466
    适用
    • 119
    • 59
    • 41
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 119
    • 7
    • 1
    克隆类型
    • 111
    • 16
    多克隆
    标记
    • 76
    • 7
    • 4
    • 4
    • 4
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    • 4
    • 4
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    • 2
    • 2
    • 1
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    This Cortactin antibody is conjugated to AbBy Fluor® 555
    应用范围
    • 92
    • 50
    • 49
    • 16
    • 13
    • 13
    • 13
    • 12
    • 11
    • 6
    • 3
    • 2
    • 1
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    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic phosphopeptide derived from human Cortactin around the phosphorylation site of Tyr466(YAp-TEA)
    亚型
    IgG
    Top Product
    Discover our top product CTTN Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    Cortactin (CTTN)
    别名
    Cortactin (CTTN 产品)
    背景

    Synonyms: Amplaxin, CTTN, EMS 1, EMS1, Mammary tumor and squamous cell carcinoma associated, Oncogene EMS1, p80/85 src substrate, Src substrate cortactin, SRC8_HUMAN.

    Background: Cortactin is an 80/85 kDa cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino terminal tandem repeats of a unique 37 amino acid sequence, which associates with actin, and a Src homology 3 (SH3) domain at the carboxyl terminus. Between the repeat and the SH3 domain, there is an alpha helical structure followed by a proline rich region. Between the proline rich region and the SH3 domain, there are a series of Src phosphorylation sites (Tyr421, Tyr470, and Tyr486). In vitro, cortactin binds to and cross links F actin into meshworks.

    基因ID
    2017
    途径
    MAPK Pathway
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