JAK2 抗体 (pTyr1007, pTyr1008) (AbBy Fluor® 647)
Quick Overview for JAK2 抗体 (pTyr1007, pTyr1008) (AbBy Fluor® 647) (ABIN878636)
抗原
See all JAK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr1007, pTyr1008
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交叉反应
- 人, 小鼠, 兔, 大鼠, 斑马鱼
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预测反应
- Pig,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyr1007/1008
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亚型
- IgG
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anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
JAK2 适用: 人, 大鼠, 小鼠, 兔, 斑马鱼 WB, ELISA, FACS, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 508-800) antibodyJAK2 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 916-1103) antibodyJAK2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 745-955) antibodyJAK2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5C12C9 unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr221) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr931) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibodyJAK2 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 1A4 unconjugated Recombinant Antibody
anti-Janus Kinase 2 (JAK2) (C-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (AA 1101-1132) antibodyJAK2 适用: 人, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 2 (JAK2) (N-Term) antibodyJAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- JAK2 (Janus Kinase 2 (JAK2))
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别名
- Jak2
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背景
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Synonyms: JAK2Tyr1007/1008, Tyrosine protein kinase JAK2, JAK 2, JAK-2, JAK2, JAK2_HUMAN, Janus Activating Kinase 2, Janus Kinase 2, JTK 10, JTK10, OTTHUMP00000043260, Tyrosine-protein kinase JAK2, Tyrosine protein kinase JAK2.
Background: JAK2 (Janus Activating Kinase 2) is a tyrosine kinase of the non-receptor type, that associates with the intracellular domains of cytokine receptors, JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin, it has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes.
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基因ID
- 3717
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UniProt
- O60674
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途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response
抗原
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