SART1 抗体 (AA 701-800)
Quick Overview for SART1 抗体 (AA 701-800) (ABIN873218)
抗原
See all SART1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 701-800
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预测反应
- Human,Mouse,Rat,Cow,Sheep,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human SART1
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- SART1 (Squamous Cell Carcinoma Antigen Recognized By T Cells (SART1))
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别名
- SART1
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背景
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Synonyms: Ara 1, ARA1, HOMS 1, HOMS1, hSART 1, hSART1, hSnu 66, hSnu66, IgE autoantigen, MGC2038, SART 1, SART1 259, SART1259 protein, SART1800 protein, SART1259, Snu 66, Snu66, Squamous cell carcinoma antigen recognised by T cells, Squamous cell carcinoma antigen recognized by T cells 1, U4/U6.U5 tri snRNP associated 110 kDa protein, U4/U6.U5 tri snRNP associated protein, SNUT1_HUMAN.
Background: SART1 encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation, its full length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri snRNP to the pre spliceosome in the spliceosome assembly pathway.
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基因ID
- 9092
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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