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Caveolin 2 抗体

This anti-Caveolin 2 antibody (ABIN872473) is a Rabbit Polyclonal antibody detecting Caveolin 2 in WB, IF (p), IHC (p). Suitable for Human, Mouse, Rat.
产品编号 ABIN872473
发货至: 中国

Quick Overview for Caveolin 2 抗体 (ABIN872473)

抗原

See all Caveolin 2 (CAV2) 抗体
Caveolin 2 (CAV2)

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Caveolin 2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Caveolin-2

    亚型

    IgG
  • 应用备注

    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C

    有效期

    12 months
  • 抗原

    Caveolin 2 (CAV2)

    别名

    Caveolin-2

    背景

    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.Tissue specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.

    Synonyms: CAV, CAV2, CAV2_HUMAN, Caveolae protein 20 kD, Caveolin 2, Caveolin2, Caveolin 2 isoform a and b, Caveolin 2 isoform c, Caveolin-2, MGC12294.

    基因ID

    858

    途径

    Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
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