The antibody detects endogenous level of total Fibrillarin protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 297-301 ( L-T-L-E-P) derived from Human Fibrillarin Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.