PKM2 抗体 (AA 36-40)
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Quick Overview for PKM2 抗体 (AA 36-40) (ABIN871666)
抗原
See all PKM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 36-40
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特异性
- The antibody detects endogenous levels of total PKM1/2 protein.
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纯化方法
- Affinity purified
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免疫原
- Peptide sequence around AA 36-40 (D-S-P-P-I) derived from Human PKM1, 2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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应用备注
- Western blotting: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- PKM2 (Pyruvate Kinase M2 (PKM2))
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别名
- PKM2
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背景
- Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
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分子量
- 60 kDa
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基因ID
- 5315
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NCBI登录号
- NP_872270
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UniProt
- P14618
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途径
- Warburg Effect
抗原
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