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SNAIL 抗体

This 小鼠 单克隆 antibody specifically detects SNAIL in WB 和 ELISA. It exhibits reactivity toward 人.
产品编号 ABIN865486
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SNAIL 抗体 (ABIN865486)

抗原

See all SNAIL (SNAI1) 抗体
SNAIL (SNAI1)

适用

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宿主

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小鼠

克隆类型

  • 78
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单克隆

标记

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This SNAIL antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA

克隆位点

6D2
  • 纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human SNAI1 expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100g/100l

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • 抗原

    SNAIL (SNAI1)

    别名

    SNAI1

    背景

    Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function . Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Synonyms: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

    分子量

    29kDa

    基因ID

    6615

    途径

    Negative Regulation of intrinsic apoptotic Signaling
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