SNAIL 抗体
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北京 101111
Quick Overview for SNAIL 抗体 (ABIN865486)
抗原
See all SNAIL (SNAI1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human SNAI1 expressed in E. Coli.
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亚型
- IgG1
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应用备注
- WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100g/100l
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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- SNAIL (SNAI1)
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别名
- SNAI1
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背景
- Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function . Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Synonyms: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1
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分子量
- 29kDa
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基因ID
- 6615
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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