Amyloid 抗体
(2 references)Quick Overview for Amyloid 抗体 (ABIN863210)
抗原
适用
宿主
克隆类型
标记
应用范围
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特异性
- Recognizes all types of amyloid oligomers. Appears to recog a peptide backbone epitope common to amyloid oligomers, but not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
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交叉反应
- Eukaryotes, 人, 小鼠, 大鼠
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纯化方法
- Protein A Purified
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免疫原
- Synthetic molecular mimic of soluble oligomers
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anti-Amyloid antibody
适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal unconjugated
anti-Amyloid antibody (HRP)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal HRP
anti-Amyloid antibody (FITC)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal FITC
anti-Amyloid antibody (Biotin)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal Biotin
anti-Amyloid antibody (PE)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal PE
anti-Amyloid antibody (PerCP)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal PerCP
anti-Amyloid antibody (APC)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal APC
anti-Amyloid antibody (Atto 488)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal Atto 488
anti-Amyloid antibody (Atto 594)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal Atto 594
anti-Amyloid antibody (Atto 390)适用: 人 ELISA, IP, IHC, WB, ICC, IF, DB 宿主: 兔 Polyclonal Atto 390
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应用备注
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- WB (1:200)
- IP (1:200)
- optimal dilutions for assays should be determined by the user.
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说明
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A 1:200 dilution of ABIN863210 was sufficient for detection of amyloid oligomers in 10 μg of mouse brain lysates by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C
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: "Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 7, pp. 9156-9179, (2020) (PubMed).
: "Acute amnestic encephalopathy in amyloid-β oligomer-injected mice is due to their widespread diffusion in vivo." in: Neurobiology of aging, Vol. 36, Issue 6, pp. 2043-52, (2015) (PubMed).
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: "Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 7, pp. 9156-9179, (2020) (PubMed).
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- Amyloid
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背景
- Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
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基因ID
- 8666
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NCBI登录号
- NM_000484
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UniProt
- P05067
抗原
-
