Amyloid 抗体 (PE)
-
- 抗原
- Amyloid
- 适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- PE
- 应用范围
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Dot Blot (DB)
- 特异性
- Recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins. Expected to detect in Mouse and Rat based on homology.
- 交叉反应
- 人
- 纯化方法
- Protein A Purified
- 免疫原
- Fibrils prepared from human amyloid beta 42 peptide
-
-
- 应用备注
-
- WB (1:1000)
- IHC (1:100)
- optimal dilutions for assays should be determined by the user.
- 说明
-
A 1:1000 dilution of ABIN2486112 was sufficient for detection of amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Conjugated antibodies should be stored at 4°C
-
- 抗原
- Amyloid
- 别名
- amyloid beta precursor protein antibody, App antibody
- 背景
- Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
-