P-Selectin 抗体 (FITC)
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北京 101111
Quick Overview for P-Selectin 抗体 (FITC) (ABIN810080)
抗原
See all P-Selectin (SELP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu CD62P FITC
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特异性
- The antibody AK4 recognizes an extracellular epitope of CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes, it is relocated to the plasma membrane upon activation.
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交叉反应 （详细）
- Human, Non-Human Primates
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纯化方法
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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免疫原
- Human platelets
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亚型
- IgG1 kappa
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anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 701-768) antibody
SELP 适用: 人, 大鼠, 小鼠, Pig WB, FACS, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 198-432) antibodySELP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 58-158) antibodySELP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 30-200) antibodySELP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibodySELP 适用: 人, Non-Human Primate WB, FACS, IP, ICC 宿主: 小鼠 Monoclonal AK4 unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 58-195) antibodySELP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) (AA 198-432) antibodySELP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C18 unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibodySELP 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibodySELP 适用: 人, Non-Human Primate WB, FACS, IP, ICC, Func 宿主: 小鼠 Monoclonal AK4 unconjugated
anti-Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) antibody (Biotin)SELP 适用: 人, Non-Human Primate WB, FACS, IP, ICC 宿主: 小鼠 Monoclonal AK4 Biotin
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应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.
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限制
- 仅限研究用
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溶解方式
- No reconstitution is necessary.
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缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
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Do not freeze.
Avoid prolonged exposure to light. -
储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules." in: The Journal of investigative dermatology, Vol. 122, Issue 3, pp. 830-6, (2004) (PubMed).
: "Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets." in: British journal of haematology, Vol. 104, Issue 2, pp. 220-9, (1999) (PubMed).
: "Enhanced activation of platelets with abnormal release of RANTES in human immunodeficiency virus type 1 infection." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 12, Issue 1, pp. 79-89, (1998) (PubMed).
: "Characterization of GMP-140 (P-selectin) as a circulating plasma protein." in: The Journal of experimental medicine, Vol. 175, Issue 4, pp. 1147-50, (1992) (PubMed).
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: "Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules." in: The Journal of investigative dermatology, Vol. 122, Issue 3, pp. 830-6, (2004) (PubMed).
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- P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
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别名
- CD62P
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背景
- Selectin P,CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.,P-selectin, GMP140, SELP, PADGEM, GRMP, LECAM3, PSEL
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基因ID
- 6403
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UniProt
- P16109
抗原
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