PDGFRA 抗体 (AA 1035-1053)
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Quick Overview for PDGFRA 抗体 (AA 1035-1053) (ABIN784591)
抗原
See all PDGFRA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1035-1053
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序列
- C-GKRNRHSSQT SEESAIETG Remarks: Antigen Modificati on: Amino acids 1035-1053
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特异性
- Recognizes Human PDGF Receptor Type A, doublet, Mr 150/170 kDa.
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交叉反应 (详细)
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Species reactivity (expected):Chicken, Frog, Mouse, Rat, Zebrafish.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography
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免疫原
- Synthetic peptide KLH-conjugated corresponding to amino acids 1035-1053 of Human PDGF.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.2 M Tris-Glycine, pH 7.4 containing 0.12 M Sodium Chloride and 0.05 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze-thaw cycles.
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- PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))
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别名
- CD140a / PDGFRA
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背景
- Platelet-derived Growth Factor Receptor Alpha (PDGFR alpha), a member of the a PDGF Receptor tyrosine kinase family, is a mediator of the biological actions of platelet-derived growth factor (PDGF). PDGF binding to PDGF receptors result in stimulation of cell growth, chemotaxis, and cell shape changes. Unlike PDGFR beta, PDGFR alpha can bind to both PDGF subunits. PDGFR alpha has been implicated in the development of spina bifida. In various mouse models, deregulated PDGFR alpha expression was found to result in congenital neural tube defects. In humans, various PDGFRA promoter haplotypes have been associated with neural tube defects.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha
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基因ID
- 5156
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NCBI登录号
- NP_006197
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling
抗原
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