HGS 抗体 (Internal Region)
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Quick Overview for HGS 抗体 (Internal Region) (ABIN784218)
抗原
See all HGS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- This antibody detects endogenous levels of total HGS protein.
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography.
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免疫原
- Synthetic peptide - KLH conjugated Remarks: Antigen Modification: Internal
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亚型
- IgG
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anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibody
HGS 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 6D11 unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (C-Term) antibodyHGS 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (Internal Region) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 548-777) antibodyHGS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 513-612) antibodyHGS 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 451-500) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (AA 301-350) antibodyHGS 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) antibodyHGS 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 3H7 unconjugated
anti-Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS) (Center) antibodyHGS 适用: 人, 小鼠, 大鼠, Cow, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS (without Mg2+, Ca2+), pH 7.4 containing 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
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别名
- HGS / HRS
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背景
- HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate, Protein pp110
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基因ID
- 9146
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NCBI登录号
- NP_004703
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途径
- EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
抗原
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