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RWDD3 抗体 (N-Term)

RWDD3 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN783831
发货至: 中国
  • 抗原 See all RWDD3 抗体
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    抗原表位
    • 12
    • 9
    • 2
    • 1
    • 1
    N-Term
    适用
    • 22
    • 7
    • 6
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 21
    • 1
    克隆类型
    • 22
    多克隆
    标记
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This RWDD3 antibody is un-conjugated
    应用范围
    • 21
    • 17
    • 15
    • 11
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody reacts to RWD domain containing 3.
    纯化方法
    Affinity chromatography
    免疫原
    17 amino acid peptide from near the amino terminus of human RWDD3.
    Top Product
    Discover our top product RWDD3 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    PBS containing 0.02 % sodium azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • 抗原
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    别名
    RWDD3 (RWDD3 产品)
    别名
    DKFZp469N1913 antibody, RSUME antibody, 2510027J23Rik antibody, 3110037C01Rik antibody, AI035684 antibody, AI662458 antibody, X2CR1 antibody, X2cr1 antibody, zgc:73229 antibody, RWD domain containing 3 antibody, RWDD3 antibody, rwdd3 antibody, Rwdd3 antibody
    背景
    RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.Synonyms: RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer
    基因ID
    25950
    NCBI登录号
    NP_001121614
    UniProt
    Q9Y3V2
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