RWDD3 抗体 (N-Term)
This anti-RWDD3 antibody is a 兔 多克隆 antibody detecting RWDD3 in WB 和 EIA. Suitable for 人, 小鼠 和 大鼠.
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Quick Overview for RWDD3 抗体 (N-Term) (ABIN783831)
抗原
See all RWDD3 抗体
RWDD3
(RWD Domain Containing 3 (RWDD3))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This RWDD3 antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- N-Term
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特异性
- This antibody reacts to RWD domain containing 3.
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纯化方法
- Affinity chromatography
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免疫原
- 17 amino acid peptide from near the amino terminus of human RWDD3.
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anti-RWD Domain Containing 3 (RWDD3) (C-Term) antibody
RWDD3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RWD Domain Containing 3 (RWDD3) (N-Term) antibodyRWDD3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- RWDD3 (RWD Domain Containing 3 (RWDD3))
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别名
- RWDD3
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背景
- RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.Synonyms: RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer
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基因ID
- 25950
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NCBI登录号
- NP_001121614
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UniProt
- Q9Y3V2
抗原
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