ALKBH2 抗体 (C-Term)
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Quick Overview for ALKBH2 抗体 (C-Term) (ABIN783675)
抗原
See all ALKBH2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 15 amino acid peptide near the carboxy terminus of human ALKBH2
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anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (AA 1-261) antibody
ALKBH2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) antibodyKD Validated ALKBH2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3840 unconjugated Recombinant Antibody
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (AA 1-261) antibodyALKBH2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (AA 108-157) antibodyALKBH2 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 2 (ALKBH2) (Middle Region) antibodyALKBH2 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, Cow, 犬, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C.
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- ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))
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别名
- ALKBH2 / ABH2
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背景
- The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA, ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.Synonyms: Alkylated DNA repair protein alkB homolog 2, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, Oxy DC1
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基因ID
- 121642
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NCBI登录号
- NP_001001655
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UniProt
- Q6NS38
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途径
- DNA Damage Repair
抗原
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