ATG101 抗体 (Center)
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北京 101111
Quick Overview for ATG101 抗体 (Center) (ABIN783665)
抗原
See all ATG101 (C12orf44) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody recognizes ATG101 and is predicted to not cross-react with other TG members.
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交叉反应 （详细）
- Species reactivity (tested):Human, Mouse, Rat.
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纯化方法
- Affinity Chromatography purified via peptide column
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免疫原
- 16 amino acid peptide near the center of Human ATG101
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anti-Chromosome 12 Open Reading Frame 44 (C12orf44) (AA 121-218) antibody
C12orf44 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 12 Open Reading Frame 44 (C12orf44) (AA 1-218) antibodyC12orf44 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 12 Open Reading Frame 44 (C12orf44) (AA 29-78) antibodyC12orf44 适用: 人, Cow, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Antibody is supplied in PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))
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别名
- ATG101
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背景
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. ATG101 also interacts with ULK1 and is essential for autophagy.Synonyms: Autophagy-related protein 101, C12orf44, PP894, UPF0453 protein C12orf44
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基因ID
- 60673
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NCBI登录号
- NP_001092143
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UniProt
- Q9BSB4
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途径
- Autophagy
抗原
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