TRMT12 抗体 (N-Term)
The 兔 多克隆 anti-TRMT12 antibody is suitable to detect TRMT12 in samples from 人 和 小鼠. It has been validated for WB 和 EIA.
产品编号 ABIN783482
发货至:
中国
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Quick Overview for TRMT12 抗体 (N-Term) (ABIN783482)
抗原
See all TRMT12 抗体
TRMT12
(tRNA Methyltransferase 12 Homolog (TRMT12))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This TRMT12 antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- N-Term
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特异性
- This antibody detects TRMT12 at N-term. TYW2 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW2 are known to exist, this antibody will detect both isoforms.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 19 amino acid peptide near the amino terminus of human TYW2
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anti-tRNA Methyltransferase 12 Homolog (TRMT12) antibody
TRMT12 适用: 人, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-tRNA Methyltransferase 12 Homolog (TRMT12) (AA 1-448) antibodyTRMT12 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))
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别名
- TRMT12
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背景
- TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.Synonyms: TRM12, TYW2, tRNA methyltransferase 12, tRNA wybutosine-synthesizing protein 2 homolog, tRNA-yW-synthesizing protein 2
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基因ID
- 55039
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NCBI登录号
- NP_060426
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UniProt
- Q53H54
抗原
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