GLS2 抗体 (Center)
Quick Overview for GLS2 抗体 (Center) (ABIN783413)
抗原
See all GLS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Center
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特异性
- This antibody detects Glutaminase liver isoform at Center. GLS2 antibody is predicted to not cross-react with other catenin family members. Multiple isoforms of GLS2 are known to exist.
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交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- 18 amino acid peptide near the center terminus of human GLS2
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anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 154-479) antibody
GLS2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (Middle Region) antibodyGLS2 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 斑马鱼, Cow, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) antibodyGLS2 适用: 人, 小鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 1758CT879-217-60 unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 241-290) antibodyGLS2 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 斑马鱼, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 498-524) antibodyGLS2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB20072 unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 41-140) antibodyGLS2 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (AA 15-602) antibodyGLS2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutaminase 2 (Liver, Mitochondrial) (GLS2) (C-Term) antibodyGLS2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))
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背景
- Phosphate-activated glutaminase, also known as Glutaminase 2 (GLS2), was initially isolated from rat liver, although it has been shown to be expressed in other tissues. Like the functionally similar, larger kidney glutaminase, GLS2 catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Expression of GLS2 is increased by p53 under both stressed and nonstressed conditions, resulting in increased levels of glutamate and ?-ketoglutarate, which in turn results in enhanced mitochondrial respiration and ATP generation. GLS2 also regulates antioxidant defense function in cells by increasing reduced glutathione levels and decreasing ROS-levels, suggesting that GLS2 acts as a mediator of p53's role in antioxidant defense in addition to its role in energy metabolism.Synonyms: GA, GLS2, L-glutaminase, L-glutamine amidohydrolase
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基因ID
- 27165
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NCBI登录号
- NP_037399
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UniProt
- Q9UI32
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途径
- Dicarboxylic Acid Transport, Warburg Effect
抗原
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