GSAP 抗体 (C-Term)
Our Local Distributor
北京 101111
Quick Overview for GSAP 抗体 (C-Term) (ABIN783371)
抗原
See all GSAP (PION) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- This antibody detects PION at C-term. Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.
-
交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
-
纯化方法
- Affinity chromatography purified via peptide column
-
免疫原
- 19 amino acid peptide near the carboxy terminus of human PION
-
-
anti-Pigeon Homolog (PION) (AA 616-854) antibody
PION 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (AA 536-565), (C-Term) antibodyPION 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (N-Term) antibodyPION 适用: 人, 大鼠, Cow, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS containing 0.02 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
-
-
- GSAP (PION) (Pigeon Homolog (PION))
-
别名
- PION / GSAP
-
背景
- Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer s disease. The β-amyloid protein precursor (APP) is cleaved by one of two β-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ?secretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog
-
基因ID
- 54103
-
NCBI登录号
- NP_059135
-
UniProt
- A4D1B5
抗原
-
