This antibody detects ZBTB7A at N-term. At least two isoforms of ZBTB7A are known to exist, this antibody will recognize both isoforms. This antibody is predicted not to cross-react with other ZBTB protein family members.
交叉反应 (详细)
Species reactivity (tested):Human, Mouse.
纯化方法
Affinity Chromatography purified via peptide column
免疫原
16 amino acid peptide near the amino terminus of Human ZBTB7A
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
浓度
1.0 mg/mL
缓冲液
PBS, 0.02 % Sodium Azide
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原
ZBTB7A
(Zinc Finger and BTB Domain Containing 7A (ZBTB7A))
别名
ZBTB7A / Pokemon
背景
The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells.Synonyms: FBI-1, FBI1, Factor binding IST protein 1, LRF, Leukemia/lymphoma-related factor, POK (POZ and Krueppel) erythroid myeloid ontogenic factor, TIP21, TTF-I-interacting peptide 21, ZBTB7, Zinc finger and BTB domain-containing protein 7A