Klotho 抗体 (Center)
Quick Overview for Klotho 抗体 (Center) (ABIN783343)
抗原
See all Klotho (KL) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Center
-
特异性
- This antibody detects Klotho at center.
-
交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
-
纯化方法
- Affinity chromatography purified via peptide column
-
免疫原
- 16 amino acid peptide near the center of human KLOTHO
-
-
anti-Klotho (KL) (AA 516-955) antibody
KL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 401-500) antibodyKL 适用: 小鼠, 人, 大鼠 IHC (p), IHC (fro), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 517-956) antibodyKL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 720-769) antibodyKL 适用: 人, 大鼠, 兔, Cow, 犬, Pig, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 251-300) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, 犬, 豚鼠, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (N-Term) antibodyKL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (Middle Region) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, Cow, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (Middle Region) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, Cow, 犬, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 765-981) antibodyKL 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 59-508) antibodyKL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
缓冲液
- PBS containing 0.02 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
-
-
- Klotho (KL)
-
别名
- Klotho
-
背景
- KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor. Three isoforms of KLOTHO are known to exist.Synonyms: EC 3.2.1.31, KL, Klotho
-
基因ID
- 9365
-
NCBI登录号
- NP_004786
-
UniProt
- Q9UEF7
-
途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding
抗原
-
