Klotho 抗体 (Middle Region)
(1 reference)Our Local Distributor
北京 101111
Quick Overview for Klotho 抗体 (Middle Region) (ABIN2776875)
抗原
See all Klotho (KL) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Middle Region
-
原理
- KL Antibody - middle region
-
序列
- HAQNGKISIA LQADWIEPAC PFSQKDKEVA ERVLEFDIGW LAEPIFGSGD
-
预测反应
- Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
-
产品特性
- This is a rabbit polyclonal antibody against KL. It was validated on Western Blot using a cell lysate as a positive control.
-
纯化方法
- Affinity Purified
-
免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human KL
-
-
anti-Klotho (KL) (AA 516-955) antibody
KL 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 401-500) antibodyKL 适用: 人 WB, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 517-956) antibodyKL 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 251-300) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, 犬, 豚鼠, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 720-769) antibodyKL 适用: 人, 大鼠, 兔, Cow, 犬, Pig, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (N-Term) antibodyKL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (Middle Region) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, Cow, 犬, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (Center) antibodyKL 适用: 小鼠, 人, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 284-315), (C-Term) antibodyKL 适用: 人 WB 宿主: 兔 Polyclonal RB55296 unconjugated
anti-Klotho (KL) (AA 765-981) antibodyKL 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41554-100UG
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 mg/mL
-
缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- prevent freeze-thaw cycles
-
储存条件
- 4 °C,-20 °C
-
储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
-
-
-
: "Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats." in: Kidney international, Vol. 87, Issue 6, pp. 1141-52, (2016) (PubMed).
-
-
- Klotho (KL)
-
别名
- KL
-
背景
-
Background Information: KL is a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Gene Name: Klotho
Alternative Symbols: HFTC3
Protein Name: Klotho
-
分子量
- 116kDa
-
基因ID
- 9365
-
NCBI登录号
- NP_004786
-
UniProt
- Q9UEF7
-
途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding
抗原
-
