ATF6 抗体 (C-Term)
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Quick Overview for ATF6 抗体 (C-Term) (ABIN783116)
抗原
See all ATF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody reacts to the C-term of ATF6.
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交叉反应 (详细)
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. -
纯化方法
- Immunoaffinity Chromatography
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免疫原
- Synthetic peptide (C-EATHVVSTIPESLQ) from C-terminus of human ATF6 Genename: ATF6
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0,5 mg/mL
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缓冲液
- Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % sodium azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- ATF6 (Activating Transcription Factor 6 (ATF6))
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别名
- ATF6 alpha
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背景
- Activating Transcription Factor 6 (ATF6) is a type II transmembrane glycoprotein located on the ER membrane. In response to ER stress ATF6 is cleaved and the N-terminus including the leucine zipper (which faces the cytosol) moves to the nucleus. Once in the nucleus ATF6 binds to the ER stress response elements in ER stress genes. Site-1 and site-2 protease enzymes that process sterol regulatory binding proteins in response to cholesterol derivation cleave ATF6.Synonyms: ATF-6, Activating transcription factor 6 alpha, Cyclic AMP-dependent transcription factor ATF-6 alpha, cAMP-dependent transcription factor ATF-6 alpha
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基因ID
- 22926
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NCBI登录号
- NP_031374
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UniProt
- P18850
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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