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ATF6 抗体 (AA 1-190)

ATF6 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1512605
发货至: 中国
  • 抗原 See all ATF6 抗体
    ATF6 (Activating Transcription Factor 6 (ATF6))
    抗原表位
    • 16
    • 15
    • 13
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-190
    适用
    • 84
    • 43
    • 33
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    宿主
    • 72
    • 12
    • 1
    克隆类型
    • 74
    • 11
    多克隆
    标记
    • 46
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This ATF6 antibody is un-conjugated
    应用范围
    • 76
    • 27
    • 27
    • 24
    • 17
    • 16
    • 14
    • 10
    • 7
    • 6
    • 6
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    序列
    MGEPAGVAGT MESPFSPGLF HRLDEDWDSA LFAELGYFTD TDELQLEAAN ETYENNFDNL DFDLDLMPWE SDIWDINNQI CTVKDIKAEP QPLSPASSSY SVSSPRSVDS YSSTQHVPEE LDLSSSSQMS PLSLYGENSN SLSSAEPLKE DKPVTGPRNK TENGLTPKKK IQVNSKPSIQ PKPLLLPAAP
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human ATF6 (NP_031374.2).
    亚型
    IgG
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze / thaw cycles
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • Jiang, He, Zhu, Liang, Wang, Lu, Ren, Yi, Xiao, Wang: "Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model." in: Experimental cell research, Vol. 369, Issue 2, pp. 325-334, (2018) (PubMed).

    Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).

    He, Xu, Gou, Yuan, Liao, Chen, Fan, Xie, Deng, Zhang, Chen, Zhao: "CSFV Infection Up-Regulates the Unfolded Protein Response to Promote Its Replication." in: Frontiers in microbiology, Vol. 8, pp. 2129, (2017) (PubMed).

  • 抗原
    ATF6 (Activating Transcription Factor 6 (ATF6))
    别名
    ATF6 (ATF6 产品)
    别名
    ATF-6-like antibody, GB16435 antibody, ATF6 antibody, Atf6 antibody, ATF6A antibody, 9130025P16Rik antibody, 9630036G24 antibody, AA789574 antibody, Atf6alpha antibody, ESTM49 antibody, activating transcription factor 6 antibody, uncharacterized LOC412432 antibody, activating transcription factor 6 S homeolog antibody, cyclic AMP-dependent transcription factor ATF-6 alpha antibody, ATF6 antibody, LOC412432 antibody, atf6.S antibody, LOC100122162 antibody, Atf6 antibody
    背景
    This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.,ATF6,ACHM7,ATF6A,Epigenetics & Nuclear Signaling,Transcription Factors,Neuroscience,Neurodegenerative Diseases,ATF6
    分子量
    74 kDa
    基因ID
    22926
    UniProt
    P18850
    途径
    ER-Nucleus Signaling, Unfolded Protein Response
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