GSTA1 抗体 (AA 1-222)
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Quick Overview for GSTA1 抗体 (AA 1-222) (ABIN782405)
抗原
See all GSTA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-222
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特异性
- This antibody reacts to GSTA1.
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纯化方法
- Affinity chromatography on Protein A
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免疫原
- GSTA1 antibody was raised against gSTA1 (AAH53578.1, 1 a.a. ~ 222 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0,5 mg/mL
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody at -20 °C to -80 °C.
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- GSTA1 (Glutathione S-Transferase alpha 1 (GSTA1))
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别名
- GSTA1
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背景
- Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.Synonyms: GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, HA subunit 1
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基因ID
- 2938
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NCBI登录号
- NP_665683
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UniProt
- P08263
抗原
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