PMS2CL/PMS2 抗体 (AA 600-700)
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北京 101111
Quick Overview for PMS2CL/PMS2 抗体 (AA 600-700) (ABIN8123821)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 600-700
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原理
- Postmeiotic Segregation Increased 2 (PMS2) mouse mAb
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特异性
- The antibody can specifically recognize human PMS2 protein.
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纯化方法
- The antibody was purified by affinity chromatography using a specific immunogen.
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免疫原
- A synthetic peptide corresponding to the amino acid region 600 - 700 of the human Postmeiotic Segregation Increased 2 protein.
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亚型
- IgG
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应用备注
- IHC, 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C
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储存方法
- Store at-20°C. Avoid freeze / thaw cycles.
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- PMS2CL/PMS2 (PMS2) (PMS1 Homolog 2, Mismatch Repair System Component (PMS2))
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别名
- Postmeiotic Segregation Increased 2
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背景
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Synonyms: DNA mismatch repair gene homologue, DNA mismatch repair protein PMS2, H_DJ0042M02. 9, HNPCC4, Mismatch repair endonuclease PMS2, Mismatch repair gene PMSL2, MLH4, PMS 2, PMS1 homolog 2 mismatch repair system, PMS1 protein homolog 2, PMS2, PMS2 postmeiotic segregation increased 2, PMS2 postmeiotic segregation increased 2 (S. cerevisiae) , PMS2_HUMAN, PMS2CL, PMSL2, Postmeiotic segregation increased, S. cerevisiae, 2
Background: Human mismatch repair genes play an important role in maintaining the integrity and stability of genetic information and avoiding genetic mutation. PMS2 is a mismatch repair protein with a molecular weight of 96 kDa, located on chromosome 7. It mainly corrects single base mismatch and small fragment mismatch in vivo. PMS2 forms heterodimer with MLH1 protein and coordinates the binding of other proteins after being activated by ATP to repair DNA errors during cell division. At present, it is mostly used for Lynch syndrome screening together with MLH1, MSH2 and MSH6.
Gene Name: PMS2
Protein Name: Postmeiotic Segregation Increased 2
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基因ID
- 5395
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UniProt
- P54278
抗原
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