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MYST2 抗体 (AA 100-200)

This 小鼠 单克隆 antibody specifically detects MYST2 in WB, ELISA 和 IF. It exhibits reactivity toward 人.
产品编号 ABIN8123180
发货至: 中国
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北京 101111
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Room 801-803
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Quick Overview for MYST2 抗体 (AA 100-200) (ABIN8123180)

抗原

See all MYST2 抗体
MYST2 (MYST Histone Acetyltransferase 2 (MYST2))

适用

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人

宿主

  • 59
  • 4
小鼠

克隆类型

  • 37
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单克隆

标记

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This MYST2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF)

克隆位点

AB2413
  • 抗原表位

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    AA 100-200

    原理

    HBO1 mouse mAb

    特异性

    This antibody detects endogenous levels of HBO1  protein.

    纯化方法

    The antibody was purified by protein G affinity chromatography.

    免疫原

    A synthetic peptide corresponding to the amino acid region 100 - 200 of the human HBO1 protein.

    亚型

    IgG
  • 应用备注

    WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid freeze / thaw cycles

    储存条件

    -20 °C

    储存方法

    Store at-20°C. Avoid freeze / thaw cycles.
  • 抗原

    MYST2 (MYST Histone Acetyltransferase 2 (MYST2))

    别名

    HBO1

    背景

    Synonyms: KAT7,HBO1,HBOa,MYST2,Histone acetyltransferase KAT7,Histone acetyltransferase binding to ORC1,Lysine acetyltransferase 7,MOZ,YBF2/SAS3, SAS2 and TIP60 protein 2,MYST-2

    Background: catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. , domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. , domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. , function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. , PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. , similarity:Belongs to the MYST (SAS/MOZ) family. , similarity:Contains 1 C2HC-type zinc finger. , subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. , tissue specificity:Ubiquitously expressed, with highest levels in testis. ,

    Gene Name: KAT7

    Protein Name: HBO1

    基因ID

    11143

    UniProt

    O95251
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