MYST2 抗体 (AA 100-200)
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Quick Overview for MYST2 抗体 (AA 100-200) (ABIN8123180)
抗原
See all MYST2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-200
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原理
- HBO1 mouse mAb
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特异性
- This antibody detects endogenous levels of HBO1 protein.
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纯化方法
- The antibody was purified by protein G affinity chromatography.
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免疫原
- A synthetic peptide corresponding to the amino acid region 100 - 200 of the human HBO1 protein.
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亚型
- IgG
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应用备注
- WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C
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储存方法
- Store at-20°C. Avoid freeze / thaw cycles.
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- MYST2 (MYST Histone Acetyltransferase 2 (MYST2))
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别名
- HBO1
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背景
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Synonyms: KAT7,HBO1,HBOa,MYST2,Histone acetyltransferase KAT7,Histone acetyltransferase binding to ORC1,Lysine acetyltransferase 7,MOZ,YBF2/SAS3, SAS2 and TIP60 protein 2,MYST-2
Background: catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. , domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. , domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. , function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. , PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. , similarity:Belongs to the MYST (SAS/MOZ) family. , similarity:Contains 1 C2HC-type zinc finger. , subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. , tissue specificity:Ubiquitously expressed, with highest levels in testis. ,
Gene Name: KAT7
Protein Name: HBO1
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基因ID
- 11143
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UniProt
- O95251
抗原
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