MMP19 抗体 (Cleaved-Tyr98)
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北京 101111
Quick Overview for MMP19 抗体 (Cleaved-Tyr98) (ABIN8122797)
抗原
See all MMP19 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Cleaved-Tyr98
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原理
- MMP19 (Cleaved-Tyr98) Antibody
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特异性
- This antibody detects endogenous levels of Human,Mouse MMP19 (Cleaved-Tyr98, protein was cleaved amino acid sequence between 97-98 )
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)
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亚型
- IgG
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anti-Matrix Metallopeptidase 19 (MMP19) (AA 98-508) antibody
MMP19 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (N-Term) antibodyMMP19 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (AA 344-373), (C-Term) antibodyMMP19 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB02035 unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (AA 56-105) antibodyMMP19 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (AA 349-398) antibodyMMP19 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (N-Term) antibodyMMP19 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (AA 251-350) antibodyMMP19 适用: 人 WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (C-Term) antibodyMMP19 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (AA 209-508) antibodyMMP19 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 19 (MMP19) (AA 1-508) antibodyMMP19 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MMP19 (Matrix Metallopeptidase 19 (MMP19))
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别名
- MMP19
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背景
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Synonyms: Matrix metalloproteinase-19 (MMP-19, EC 3.4.24.-, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18)
Background: alternative products:Additional isoforms seem to exist,catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient.,function:Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.,PTM:Activated by autolytic cleavage after Lys-97.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.,
Gene Name: MMP19 MMP18 RASI
Protein Name: MMP19 (Cleaved-Tyr98)
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基因ID
- 4327
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UniProt
- Q99542
抗原
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