MASP1 抗体 (Cleaved-Ile449, Light Chain)
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Quick Overview for MASP1 抗体 (Cleaved-Ile449, Light Chain) (ABIN8122756)
抗原
See all MASP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Cleaved-Ile449, Light Chain
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原理
- MASP1 (light chain, Cleaved-Ile449) Antibody
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特异性
- This antibody detects endogenous levels of Human MASP1 (light chain, Cleaved-Ile449, protein was cleaved amino acid sequence between 448-449 )
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human MASP1 (light chain, Cleaved-Ile449)
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亚型
- IgG
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anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (AA 20-447) antibody
MASP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (AA 25-453) antibodyMASP1 适用: 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (AA 20-120) antibodyMASP1 适用: 人 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (AA 1-380) antibodyMASP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (AA 481-507) antibodyMASP1 适用: 人 WB 宿主: 兔 Polyclonal RB22401 unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (cleaved), (Internal Region) antibodyMASP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (AA 20-699) antibodyMASP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (Arg448), (cleaved) antibodyMASP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mannan-Binding Lectin Serine Peptidase 1 (MASP1) (AA 1-380) antibodyMASP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
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别名
- MASP1
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背景
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Synonyms: Mannan-binding lectin serine protease 1 (EC 3.4.21.-, Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain]
Background: enzyme regulation:Inhibited by SERPING1 and A2M.,function:Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.,PTM:Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing.,PTM:N-glycosylated. Some N-linked glycan are of the complex-type.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3, triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.,tissue specificity:Protein of the plasma which is primarily expressed by liver.,
Gene Name: MASP1 CRARF CRARF1 PRSS5
Protein Name: MASP1 (light chain, Cleaved-Ile449)
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基因ID
- 5648
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UniProt
- P48740
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途径
- Complement System
抗原
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