JAK3 抗体 (pTyr981)
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北京 101111
Quick Overview for JAK3 抗体 (pTyr981) (ABIN8122385)
抗原
See all JAK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr981
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原理
- JAK3 (Phospho Tyr981) Antibody
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特异性
- This antibody detects endogenous levels of Human,Mouse,Rat JAK3 (Phospho Tyr981)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human JAK3 (Phospho Tyr981)
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亚型
- IgG
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anti-Janus Kinase 3 (JAK3) (AA 716-967) antibody
JAK3 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 3 (JAK3) antibodyJAK3 适用: 人, 小鼠 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5H2 unconjugated
anti-Janus Kinase 3 (JAK3) (AA 601-700) antibodyJAK3 适用: 人 WB, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 3 (JAK3) antibodyJAK3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 3 (JAK3) (pTyr980), (pTyr981) antibodyJAK3 适用: 人 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 3 (JAK3) (AA 750-850) antibodyJAK3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 3 (JAK3) (Tyr785) antibodyJAK3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 3 (JAK3) antibodyJAK3 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 1C7 unconjugated Recombinant Antibody
anti-Janus Kinase 3 (JAK3) (pTyr785) antibodyJAK3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 3 (JAK3) (Ser645) antibodyJAK3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- JAK3 (Janus Kinase 3 (JAK3))
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别名
- JAK3
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背景
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Synonyms: Tyrosine-protein kinase JAK3 (EC 2.7.10.2, Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK)
Background: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in JAK3 are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-)SCID) [MIM:600802]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,function:Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.,online information:JAK3 mutation db,PTM:Tyrosine phosphorylated in response to IL-2 and IL-4.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.,tissue specificity:In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins.,
Gene Name: JAK3
Protein Name: JAK3 (Phospho Tyr981)
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基因ID
- 3718
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UniProt
- P52333
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途径
- JAK/STAT Signaling, RTK signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response
抗原
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