IGF2R 抗体 (pSer2484)
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Quick Overview for IGF2R 抗体 (pSer2484) (ABIN8122240)
抗原
See all IGF2R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer2484
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原理
- IGF2R (Phospho Ser2484) Antibody
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特异性
- This antibody detects endogenous phospho levels of IGF2R (Phospho-Ser2484) at Human:S2484, Mouse:S2476, Rat:S2472
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human IGF2R (Phospho-Ser2484)
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亚型
- IgG
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应用备注
- IHC 1:50-200, WB 1:500-2000. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
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别名
- IGF2R
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背景
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Synonyms: Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, CD antigen CD222)
Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele, however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015],
Gene Name: IGF2R MPRI
Protein Name: IGF2R (Phospho-Ser2484)
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基因ID
- 3482
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UniProt
- P11717
抗原
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