Granulin 抗体 (AA 541-590)
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北京 101111
Quick Overview for Granulin 抗体 (AA 541-590) (ABIN8121808)
抗原
See all Granulin (GRN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 541-590
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原理
- Acrogranin Antibody
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特异性
- This antibody detects endogenous levels of Human Acrogranin
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from human Acrogranin AA range: 541-590
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亚型
- IgG
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anti-Granulin (GRN) (AA 361-585) antibody
GRN 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 31-269) antibodyGRN 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) antibodyKD Validated GRN 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB6595 unconjugated
anti-Granulin (GRN) (Center) antibodyGRN 适用: 人, 小鼠, 大鼠 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 451-550) antibodyGRN 适用: 人 WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 563-591), (C-Term) antibodyGRN 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB44397 unconjugated
anti-Granulin (GRN) (AA 44-255) antibodyGRN 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Granulin (GRN) (AA 494-593) antibodyGRN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1F5 unconjugated
anti-Granulin (GRN) (AA 494-593) antibodyGRN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Granulin (GRN) (Internal Region) antibodyVerified GRN 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Granulin (GRN)
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别名
- Acrogranin
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背景
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Synonyms: Granulins (Proepithelin, PEPI) [Cleaved into: Acrogranin, Paragranulin, Granulin-1 (Granulin G), Granulin-2 (Granulin F), Granulin-3 (Granulin B), Granulin-4 (Granulin A), Granulin-5 (Granulin C), Granulin-6 (Granulin D), Granulin-7 (Granulin E)]
Background: disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.,function:Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.,function:Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.,PTM:Granulins are disulfide bridged.,similarity:Belongs to the granulin family.,tissue specificity:In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.,
Gene Name: GRN
Protein Name: Acrogranin
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基因ID
- 2896
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UniProt
- P28799
抗原
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