FOXO3 抗体 (acLys569)
Our Local Distributor
北京 101111
Quick Overview for FOXO3 抗体 (acLys569) (ABIN8121505)
抗原
See all FOXO3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- acLys569
-
原理
- FoxO3A (Acetyl Lys569) Antibody
-
特异性
- This antibody detects endogenous levels of Human,Mouse,Rat FoxO3A (Acetyl Lys569)
-
纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
-
免疫原
- Synthesized peptide derived from human FoxO3A (Acetyl Lys569)
-
亚型
- IgG
-
-
anti-Forkhead Box O3 (FOXO3) (C-Term) antibody
Verified FOXO3 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (pSer318), (pSer321) antibodyFOXO3 适用: 人 WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (C-Term) antibodyKO Validated FOXO3 适用: 人 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (AA 471-673) antibodyFOXO3 适用: 人, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (N-Term) antibodyFOXO3 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 绵羊, 兔, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) (N-Term) antibodyFOXO3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box O3 (FOXO3) antibodyFOXO3 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 1E2 unconjugated Recombinant Antibody
anti-Forkhead Box O3 (FOXO3) (AA 361-460) antibodyFOXO3 适用: 人 ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Forkhead Box O3 (FOXO3) (AA 361-460) antibodyFOXO3 适用: 人 ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1F6 unconjugated
anti-Forkhead Box O3 (FOXO3) (pSer253) antibodyFOXO3 适用: 人 WB, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- FOXO3 (Forkhead Box O3 (FOXO3))
-
别名
- FoxO3A
-
背景
-
Synonyms: Forkhead box protein O3 (AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1)
Background: disease:A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6,11)(q21,q23) with MLL/HRX.,function:Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.,PTM:In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation.,similarity:Contains 1 fork-head DNA-binding domain.,subcellular location:Translocates to the nucleus upon oxidative stress and in the absence of survival factors.,subunit:Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation.,tissue specificity:Ubiquitous.,
Gene Name: FOXO3 FKHRL1 FOXO3A
Protein Name: FoxO3A (Acetyl Lys569)
-
基因ID
- 2309
-
UniProt
- O43524
-
途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
抗原
-
