MIB2 抗体
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北京 101111
Quick Overview for MIB2 抗体 (ABIN8121115)
抗原
See all MIB2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MIB2 Antibody
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特异性
- MIB2 Polyclonal Antibody detects endogenous levels of protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from part region of human protein
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亚型
- IgG
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anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 687-930) antibody
MIB2 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 546-784) antibodyMIB2 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 381-480) antibodyMIB2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1B5 unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 216-249) antibodyMIB2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB54754 unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 300-580) antibodyMIB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 1-128) antibodyMIB2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 381-480) antibodyMIB2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-E3 ubiquitin-protein ligase MIB2 (MIB2) (AA 407-663) antibodyMIB2 适用: 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MIB2 (E3 ubiquitin-protein ligase MIB2 (MIB2))
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别名
- MIB2
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背景
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Background: function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.,pathway:Protein modification, protein ubiquitination.,PTM:Ubiquitinated. Possibly via autoubiquitination.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 MIB/HERC2 domains.,similarity:Contains 2 RING-type zinc fingers.,similarity:Contains 9 ANK repeats.,subcellular location:Colocalizes with endosomal compartments.,subunit:Interacts with actin monomer.,tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.,
Gene Name: MIB2 SKD ZZANK1
Protein Name: E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)
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基因ID
- 142678
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UniProt
- Q96AX9
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途径
- Notch Signaling
抗原
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