CYBB 抗体
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北京 101111
Quick Overview for CYBB 抗体 (ABIN8120856)
抗原
See all CYBB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- NOX2 Rabbit mAb
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特异性
- This antibody detects endogenous levels of NOX2 protein.
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纯化方法
- The antibody was purified by protein A affinity chromatography.
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免疫原
- Recombinant protein (or fragment).
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亚型
- IgG
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应用备注
- WB, 1:1000-1:5000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C
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储存方法
- Store at-20°C. Avoid freeze / thaw cycles.
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- CYBB (Cytochrome B-245, beta Polypeptide (CYBB))
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别名
- NOX2
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背景
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Synonyms: CYBB, NOX2, Cytochrome b-245 heavy chain, CGD91-phox, Cytochrome b (558) subunit beta, Cytochrome b558 subunit beta, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2Neutrophil cytochrome b 91 kDa polypeptide, Superoxide-generating NADPH oxidase heavy chain subunit, gp91-1, gp91-phox, p22 phagocyte B-cytochrome
Background: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD) . In this disorder, there is decreased activity of phagocyte NADPH oxidase, neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell&apos, s respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008],
Gene Name: CYBB
Protein Name: NOX2
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基因ID
- 1536
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UniProt
- P04839
抗原
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