CTNND1 抗体 (AA 600-700)
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北京 101111
Quick Overview for CTNND1 抗体 (AA 600-700) (ABIN8120250)
抗原
See all CTNND1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 600-700
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原理
- p120 catenin Mouse mAb (Ready to Use)
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特异性
- The antibody can specifically recognize human p120 catenin protein.
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纯化方法
- The antibody was purified by protein G affinity chromatography.
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免疫原
- A synthetic peptide corresponding to the amino acid region 600 - 700 of the human p120 catenin protein.
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亚型
- IgG
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应用备注
- It has been optimized for direct use, requiring no further dilution.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The ready - to - use antibody is provided in liquid form in phosphate buffer saline containing stabilizing protein and 0. 05 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze
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储存条件
- 4 °C
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储存方法
- Store at 4°C. Avoid freeze.
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- CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
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别名
- p120 catenin
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背景
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Synonyms: Cadherin associated Src substRate, Cadherin-associated Src substRate, CAS, Catenin (cadherin associated protein) delta 1, Catenin delta 1, Catenin delta, Catenin delta-1, CTND1_HUMAN, CTNND 1, CTNND, CTNND1, delta 1 Catenin, KIAA0384, p120, P120 CAS, p120 catenin, P120 CTN, p120 (cas) , p120 (ctn) , P120CAS, P120CTN
Background: α- Catenin, β- Catenin, γ- catenin and p120 catenin are members of the connexin family and mediate intercellular adhesion together with E- cadherin. P120 catenin binds to the near membrane region of E- cadherin to form a complex, which is stable and closely linked. In lobular breast cancer, E- cadherin deficiency resulted in the accumulation of p120 catenin in the cytoplasm, while in ductal breast cancer, p120 catenin in the membrane decreased and there was no accumulation of p120 catenin in the cytoplasm. Therefore, it can be used to distinguish lobular carcinoma from ductal carcinoma. Studies have shown that p120 catenin in the cytoplasm of gastric and colon cancer is related to poor adhesion of cancer cells.
Gene Name: CTNND1
Protein Name: p120 catenin
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基因ID
- 1500
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UniProt
- O60716
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
抗原
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